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Antibacteria Activity and Dermal Acute Toxicity Test in Antiacne Facial Wash from Ethanol Extract of Papaya Seeds (Carica papaya L)

Proceeding from jhptump / 2018-01-12 07:19:32
By : Rusli Triawan, Pri Iswati Utami, Erza Genatrika, Universitas Muhammadiyah Purwokerto (
Created : 2018-01-12, with 1 files

Keyword : Papaya seeds, acne, facial wash, antibacteria, acute toxicity dermal

Papaya seeds (Carica papaya L.) are reported to contain compounds which act as an antibacterial activity. The previous research on the formulation of papaya seeds extract facial wash proved to be effective to Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus) bacteria. The objective of this research is to find out the effectiveness of papaya seeds extract facial wash towards P. acnes and Staphlococcus epidermidis (S.epidermidis) bacteria and to determine Lethal Dose50 (LD50) value in order to set the dose level. This research use experimental method on the antibacterial activity test in facial wash by variant of extract concentration in different formula. This research is also use nonexperimental method which is used in acute toxicity dermal. The result shows that there is antibacterial capability from the extract on P. acnes and S. Epidermidis bacteria. Then, the researcher performed acute toxicity dermal test using wistar white rat which was tested at the dose of 50, 200, 1000, and 2000 mg/kg of weight (W). The highest dose do not cause toxicity symptom on the skin until 14 days of observation. It can be concluded that the extract and formula of papaya seeds facial wash have an antibacterial activity to P. acnes and S. epidermidis, and it does not cause toxicity symptom on skin and does not cause death to a maximum dose (2000 mg/kg W).

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