Path: TopInternational Seminar ProceedingIrecomsIrecoms 2017

PRECLINICAL STUDY OF ANTIAGING ACTIVITY OF TETRAHIDROCURCUMIN, PEGAGAN EXTRACT (CENTELLA ASIATICA), AND COMBINATION OF TETRAHIDROCURCUMIN-PEGAGAN EXTRACT

Proceeding from jhptump / 2017-11-29 12:01:20
Oleh : Ika Yuni Astuti, Ani Yupitawati, Nunuk Aries Nurulita, Universitas Muhammadiyah Purwokerto (ikayuniash@gmail.com, ani.yupitawati@gmail.com, nunuknurulita@yahoo.com)
Dibuat : 2017-11-08, dengan 0 file

Keyword : tetrahydrocurcumin, pegagan extract, antiaging.

Tetrahydrocurcumin has strong antioxidant activity and depigmentation of the skin. Pegagan extract is able to stimulate the formation of collagen, thus reducing wrinkles in aging skin. The combination of tetrahydrocurcumin (THC) and pegagan extracts (PE) is expected to result in improvements to various parameters of premature aging. This study used pre-test post-test control group design. Mice were randomized into 5 test groups. The dorsal part of the mice was shaved and then various anti aging parameters including skin sensitivity, moisture content, collagen levels, elasticity, and large pore were measured using skin analyzer. Furthermore, the dorsal was smeared with a cream base for the negative control group, a cream containing ethyl ascorbyl ether for the positive control group, a cream containing THC for THC group, a cream containing PE for the PE group, and a cream containing THC and PE for the Combination group, each with a dose of 2 mg / cm2 before and after UV irradiation. After treatment for 4 weeks, the anti aging parameters were measured again. The combination of THC and PE can increase collagen and elasticity levels compared to THC and EP itself, but the increase is not significant. Based on scores of all anti aging parameters, THC and EP combinations don’t provide greater anti aging activity than THC and EP without combination.

Deskripsi Alternatif :

Tetrahydrocurcumin has strong antioxidant activity and depigmentation of the skin. Pegagan extract is able to stimulate the formation of collagen, thus reducing wrinkles in aging skin. The combination of tetrahydrocurcumin (THC) and pegagan extracts (PE) is expected to result in improvements to various parameters of premature aging. This study used pre-test post-test control group design. Mice were randomized into 5 test groups. The dorsal part of the mice was shaved and then various anti aging parameters including skin sensitivity, moisture content, collagen levels, elasticity, and large pore were measured using skin analyzer. Furthermore, the dorsal was smeared with a cream base for the negative control group, a cream containing ethyl ascorbyl ether for the positive control group, a cream containing THC for THC group, a cream containing PE for the PE group, and a cream containing THC and PE for the Combination group, each with a dose of 2 mg / cm2 before and after UV irradiation. After treatment for 4 weeks, the anti aging parameters were measured again. The combination of THC and PE can increase collagen and elasticity levels compared to THC and EP itself, but the increase is not significant. Based on scores of all anti aging parameters, THC and EP combinations don’t provide greater anti aging activity than THC and EP without combination.

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ID Publisherjhptump
OrganisasiUniversitas Muhammadiyah Purwokerto
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