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Pharmacogenetics of drug–drug interaction and drug–drug–gene interaction: a systematic review on CYP2C9, CYP2C19 and CYP2D6

Journal from jhptump / 2018-08-16 11:39:18
Oleh : Muh Akbar Bahar, Didik Setiawan, Eelko Hak & Bob Wilffert, Universitas Muhammadiyah Purwokerto
Dibuat : 2018-08-16, dengan 1 file

Keyword : CYP2C19, CYP2C9, CYP2D6, drug–drug–gene interaction (DDGI), drug–drug interaction (DDI), drug-metabolizing enzyme

Currently, most guidelines on drug–drug interaction (DDI) neither consider the potential effect of genetic polymorphism in the strength of the interaction nor do

they account for the complex interaction caused by the combination of DDI and drug–gene interaction (DGI) where there are multiple biotransformation pathways, which

is referred to as drug–drug–gene interaction (DDGI). In this systematic review, we report the impact of pharmacogenetics on DDI and DDGI in which three major drugmetabolizing enzymes–CYP2C9, CYP2C19 and CYP2D6–

are central. We observed that several DDI and DDGI are

highly gene-dependent, leading to a different magnitude

of interaction. Precision drug therapy should take pharmacogenetics into account when drug interactions in clinical practice are expected.

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